Ontology highlight
ABSTRACT:
SUBMITTER: Balcerek B
PROVIDER: S-EPMC7547706 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Balcerek Björn B Steinach Mathias M Lichti Julia J Maggioni Martina A MA Becker Philipp N PN Labes Robert R Gunga Hanns-Christian HC Persson Pontus B PB Fähling Michael M
Scientific reports 20201009 1
Oxygen affinity to haemoglobin is indicated by the p50 value (pO<sub>2</sub> at 50% O<sub>2</sub>Hb) and critically determines cellular oxygen availability. Although high Hb-O<sub>2</sub> affinity can cause tissue hypoxia under conditions of well O<sub>2</sub> saturated blood, individual differences in p50 are commonly not considered in clinical routine. Here, we investigated the diversity in Hb-O<sub>2</sub> affinity in the context of physiological relevance. Oxyhaemoglobin dissociation curves ...[more]