Ontology highlight
ABSTRACT:
SUBMITTER: Mylvaganam S
PROVIDER: S-EPMC7548125 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Mylvaganam Sivakami S Riedl Magdalena M Vega Anthony A Collins Richard F RF Jaqaman Khuloud K Grinstein Sergio S Freeman Spencer A SA
Cell reports 20200601 12
Multivalent complexes of endothelial adhesion receptors (e.g., selectins) engage leukocytes to orchestrate their migration to inflamed tissues. Proper anchorage and sufficient density (clustering) of endothelial receptors are required for efficient leukocyte capture and rolling. We demonstrate that a polarized spectrin network dictates the stability of the endothelial cytoskeleton, which is attached to the apical membrane, at least in part, by the abundant transmembrane protein CD44. Single-part ...[more]