Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC7549570 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Biao B Chen Yongsheng Y Dai Pingping P Yu Haoda H Ma Jianhui J Chen Chen C Zhang Yan Y Guan Yanfang Y Chen Rongrong R Liu Tao T Wang Jiayin J Yang Ling L Yi Xin X Xia Xuefeng X Ma Haitao H
Molecular genetics & genomic medicine 20200805 10
<h4>Background</h4>β3-αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3-αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly focus on β3-αC deletion in EGFR, which is the most common type affecting kinase activity and driving lung cancer. Other mutation types are not well studied.<h4>Methods</h4>Here we analyzed the profile of ...[more]