Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.

ABSTRACT:

Background

β3-αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3-αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly focus on β3-αC deletion in EGFR, which is the most common type affecting kinase activity and driving lung cancer. Other mutation types are not well studied.

Methods

Here we analyzed the profile of β3-αC loop mutations in a total of 10,000 tumor biopsy and/or ctDNA patient samples using hybridization capture-based next-generation sequencing.

Results

We identified 1616 mutations within β3-αC loop in this cohort. Most mutations were located in EGFR, with less percentage in ERBB2, BRAF, an

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7549570 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature