Ontology highlight
ABSTRACT:
SUBMITTER: Mahmud SA
PROVIDER: S-EPMC7549759 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mahmud Siraje Arif SA Qureshi Mohammed Adnan MA Sapkota Madhab M Pellegrino Mark W MW
PLoS pathogens 20200930 9
The mitochondrial unfolded protein response (UPRmt) is a stress-activated pathway promoting mitochondrial recovery and defense against infection. In C. elegans, the UPRmt is activated during infection with the pathogen Pseudomonas aeruginosa-but only transiently. As this may reflect a pathogenic strategy to target a pathway required for host survival, we conducted a P. aeruginosa genetic screen to uncover mechanisms associated with this temporary activation. Here, we find that loss of the P. aer ...[more]