Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC7552186 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Guo G Tian Yuan Y Zhu Wei-Guo WG
Frontiers in cell and developmental biology 20200929
Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (N<sup>ε</sup>) of histone lysine residues is a common site for post-translational modifications (PTMs), and of these, acetylation is the second most common. Histone acetylation is modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), and is involved in t ...[more]