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Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.

ABSTRACT: BACKGROUND:Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients. METHODS:187 primary skull base chordoma patients between January 2008 and September 2014 were enrolled in this retrospective study. The optimal cut-off values were determined by X-tile software, and the correlations between PLT, MPV, PDW and clinicopathological features were further analysed. Kaplan-Meier curve and Cox regression analysis were used for survival analysis. RESULTS:The values of preoperative PTL, MPV and PDW ranged from 104 to 501?×?109/L, 6.7 to 14.2?fl, and 7.8 to 26.2%, respectively. Elevated PLT was associated with larger tumour volume (p?=?0.002). Kaplan-Meier survival analysis revealed that increased MPV and PDW were associated with shorter overall survival (p?=?0.022 and 0.008, respectively). Importantly, multivariate Cox analysis demonstrated that elevated PDW was an independent unfavourable predictive factor for overall survival (hazard ratio (HR), 2.154, 95% confidence interval (CI), 1.258-3.688, p?=?0.005). CONCLUSIONS:Our data show that elevated MPV and PDW are associated with poor outcomes in skull base chordoma and that PDW may be helpful to identify patients with high risk.

SUBMITTER: Li M

PROVIDER: S-EPMC7552483 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.

Li Mingxuan M Bai Jiwei J Wang Shuai S Zhai Yixuan Y Zhang Shuheng S Li Chuzhong C Du Jiang J Zhang Yazhuo Y

BMC cancer 20201012 1

<h4>Background</h4>Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients.<h4>Methods</h4>187 primary skull base chordoma patients between January 2008 a ...[more]

PMID: 33046024

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Project description:In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available clinical tests that reflect responses of the bone marrow and/or plasma thrombogenicity (e.g., inflammation), and can be markers for major adverse cardiac events (MACE). We aimed to evaluate if RDW and MPV may be employed as inexpensive, routinely obtained biomarkers in predicting myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) in psoriatic and psoriatic arthritis patients. The study was divided into two parts: (a) case control study employing big data (Explorys) to assess MPV and RDW in psoriasis, psoriatic arthritis and control cohorts; (b) a clinical observational study to validate the predictive value of RDW and to evaluate RDW response to anti-psoriatic therapies. We used Explorys, an aggregate electronic database, to identify psoriatic patients with available MPV and RDW data and compared them to gender and age matched controls. The incidence of myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) was highest among patients with both elevated RDW and MPV, followed by patients with high RDW and normal MPV. RDW elevation among PsA patients was associated with an increased risk of MI, AF, and CHF. In a local clinical cohort, high RDWs were concentrated in a subset of patients who also had elevated circulating resistin levels. Among a small subset of participants who were treated with various systemic and biologic therapies, and observed over a year, and in whom RDW was elevated at baseline, a sustained response to therapy was associated with a decrease in RDW. RDW and MPV, tests commonly contained within routine complete blood count (CBC), may be a cost-effective manner to identify PsO and PsA patients at increased risk of MACE.

Dataset Information

Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.

Publications

Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.

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