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Human skull base chordoma LC-MSMS

ABSTRACT: The prognostic factors of skull base chordoma associated with outcomes of patients after surgical resection remain poorly defined. This project aimed to identify a novel prognostic factor for patients with skull base chordoma. Using a proteomics approach, we screened tumor biomarkersthat upregulated in the rapid-recurrence group of chordoma, narrowed down by bioinformatics analysis, and finally potential biomarker was chosen for validation by immunohistochemistry using tissue microarray.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell

DISEASE(S): Brain Cancer

SUBMITTER: Yutao Shen

LAB HEAD: Yazhuo Zhang

PROVIDER: PXD025894 | Pride | 2021-11-03

REPOSITORIES: Pride

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Proteomics Analysis Identified ASNS as a Novel Biomarker for Predicting Recurrence of Skull Base Chordoma.

Shen Yutao Y Li Mingxuan M Xiong Yujia Y Gui Songbai S Bai Jiwei J Zhang Yazhuo Y Li Chuzhong C

Frontiers in oncology 20210901

<h4>Background</h4>The prognostic factors of skull base chordoma associated with outcomes of patients after surgery remain inadequately identified. This study was designed to identify a novel prognostic factor for patients with skull base chordoma.<h4>Method</h4>Using a proteomic technique, the tumor biomarkers that were upregulated in the rapid-recurrence group of chordoma were screened and then narrowed down by bioinformatic analysis. Finally one potential biomarker was chosen for validation b ...[more]

PMID: 34540668

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