Ontology highlight
ABSTRACT:
SUBMITTER: Thudium CS
PROVIDER: S-EPMC7552555 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Thudium Christian S CS Bay-Jensen Anne C AC Cahya Suntara S Dow Ernst R ER Karsdal Morten A MA Koch Alisa E AE Zhang Wenling W Benschop Robert J RJ
Arthritis research & therapy 20201012 1
<h4>Background</h4>Tissue released blood-based biomarkers can provide insight into drug mode of action and response. To understand the changes in extracellular matrix turnover, we analyzed biomarkers associated with joint tissue turnover from a phase 3, randomized, placebo-controlled study of baricitinib in patients with active rheumatoid arthritis (RA).<h4>Methods</h4>Serum biomarkers associated with synovial inflammation (C1M, C3M, and C4M), cartilage degradation (C2M), bone resorption (CTX-I) ...[more]