Ontology highlight
ABSTRACT:
SUBMITTER: Azangou-Khyavy M
PROVIDER: S-EPMC7553049 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Azangou-Khyavy Mohammadreza M Ghasemi Mobina M Khanali Javad J Boroomand-Saboor Melika M Jamalkhah Monire M Soleimani Masoud M Kiani Jafar J
Frontiers in immunology 20200929
The clustered regularly interspaced short palindromic repeats system has demonstrated considerable advantages over other nuclease-based genome editing tools due to its high accuracy, efficiency, and strong specificity. Given that cancer is caused by an excessive accumulation of mutations that lead to the activation of oncogenes and inactivation of tumor suppressor genes, the CRISPR/Cas9 system is a therapy of choice for tumor genome editing and treatment. In defining its superior use, we have re ...[more]