Ontology highlight
ABSTRACT:
SUBMITTER: Rajak S
PROVIDER: S-EPMC7554540 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Frontiers in cell and developmental biology 20200901
The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activating kinase 1 (ULK1) in regulating the expression of the hepatic <i>de novo</i> cholesterol biosynthesis/MVA pathway genes. Genetic silencing of ULK1 in non-starved mouse (AML-12) and human (HepG2) hepatic cells as well as in mouse liver followed by ...[more]