Ontology highlight
ABSTRACT:
SUBMITTER: Piezzo M
PROVIDER: S-EPMC7554788 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Piezzo Michela M Cocco Stefania S Caputo Roberta R Cianniello Daniela D Gioia Germira Di GD Lauro Vincenzo Di VD Fusco Giuseppina G Martinelli Claudia C Nuzzo Francesco F Pensabene Matilde M De Laurentiis Michelino M
International journal of molecular sciences 20200904 18
Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast cancer lending support to the development of drugs targeting the cell cycle control machinery, like the inhibitors of the cycline-dependent kinases (CDK) 4 and 6. Up to now, three CDK4/6 inhibitors have been approved by FDA for the treatment of hormone receptor-positive (HR+), HER2-negative metastatic breast cancer. These agents have been effective in improving the clinical outcomes, but the development of ...[more]