Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications.
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SUBMITTER: Liu Y
PROVIDER: S-EPMC7554955 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications.
Liu Yang Y Lang Fengchao F Chou Fu-Ju FJ Zaghloul Kareem A KA Yang Chunzhang C
Biomedicines 20200820 9
Mutations in isocitrate dehydrogenase (<i>IDH</i>) are commonly observed in lower-grade glioma and secondary glioblastomas. <i>IDH</i> mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts cellular epigenetics and metabolism. <i>IDH</i> mutation establishes distinctive patterns in metabolism, cancer biology, and the therapeutic sensitivity of glioma. Thus, a deeper understanding of the roles of <i>IDH</i> mutations is o ...[more]
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