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In Vitro Innovation of Tendon Tissue Engineering Strategies.

ABSTRACT: Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal biomechanical properties, often resulting in poor and painful mobility. The biomechanical properties of the tissue are negatively affected. Adult tendons have a limited natural healing capacity, and often respond poorly to current treatments that frequently are focused on exercise, drug delivery, and surgical procedures. Therefore, it is of great importance to identify key molecular and cellular processes involved in the progression of tendinopathies to develop effective therapeutic strategies and drive the tissue toward regeneration. To treat tendon diseases and support tendon regeneration, cell-based therapy as well as tissue engineering approaches are considered options, though none can yet be considered conclusive in their reproduction of a safe and successful long-term solution for full microarchitecture and biomechanical tissue recovery. In vitro differentiation techniques are not yet fully validated. This review aims to compare different available tendon in vitro differentiation strategies to clarify the state of art regarding the differentiation process.

SUBMITTER: Citeroni MR

PROVIDER: S-EPMC7555358 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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In Vitro Innovation of Tendon Tissue Engineering Strategies.

Citeroni Maria Rita MR Ciardulli Maria Camilla MC Russo Valentina V Della Porta Giovanna G Mauro Annunziata A El Khatib Mohammad M Di Mattia Miriam M Galesso Devis D Barbera Carlo C Forsyth Nicholas R NR Maffulli Nicola N Barboni Barbara B

International journal of molecular sciences 20200914 18

Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal biomechanical properties, often resulting in poor and painful mobility. The biomechanical properties of the tissue are negatively affected. Adult tendons have a limited natural healing capacity, and often respond poorly to current treatments that frequently are focused on exercise, drug delivery, and surgical procedures. Therefore, it is of gr ...[more]

PMID: 32937830

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In Vitro Innovation of Tendon Tissue Engineering Strategies.

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In Vitro Innovation of Tendon Tissue Engineering Strategies.

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