Ontology highlight
ABSTRACT:
SUBMITTER: Mimouna S
PROVIDER: S-EPMC7555412 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mimouna Sanda S Rollins David A DA Shibu Gayathri G Tharmalingam Bowranigan B Deochand Dinesh K DK Chen Xi X Oliver David D Chinenov Yurii Y Rogatsky Inez I
The Journal of experimental medicine 20210101 1
Macrophages (MФ) and microglia (MG) are critical in the pathogenesis of multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE). Glucocorticoids (GCs) and interferon β (IFN-β) are frontline treatments for MS, and disrupting each pathway in mice aggravates EAE. Glucocorticoid receptor-interacting protein 1 (GRIP1) facilitates both GR and type I IFN transcriptional actions; hence, we evaluated the role of GRIP1 in neuroinflammation. Surprisingly, myeloid cell-s ...[more]