Ontology highlight
ABSTRACT:
SUBMITTER: Peyret H
PROVIDER: S-EPMC7555512 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Peyret Hadrien H Ponndorf Daniel D Meshcheriakova Yulia Y Richardson Jake J Lomonossoff George P GP
Scientific reports 20201013 1
Virus-like particles (VLPs) can be used as nano-carriers and antigen-display systems in vaccine development and therapeutic applications. Conjugation of peptides or whole proteins to VLPs can be achieved using different methods such as the SpyTag/SpyCatcher system. Here we investigate the conjugation of tandem Hepatitis B core (tHBcAg) VLPs and the model antigen GFP in vivo in Nicotiana benthamiana. We show that tHBcAg VLPs could be successfully conjugated with GFP in the cytosol and ER without ...[more]