Ontology highlight
ABSTRACT:
SUBMITTER: Esteves F
PROVIDER: S-EPMC7555755 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Esteves Francisco F Urban Philippe P Rueff José J Truan Gilles G Kranendonk Michel M
International journal of molecular sciences 20200911 18
The activity of microsomal cytochromes P450 (CYP) is strictly dependent on the supply of electrons provided by NADPH cytochrome P450 oxidoreductase (CPR). The variant nature of the isoform-specific proximal interface of microsomal CYPs implies that the interacting interface between the two proteins is degenerated. Recently, we demonstrated that specific CPR mutations in the FMN-domain (FD) may induce a gain in activity for a specific CYP isoform. In the current report, we confirm the CYP isoform ...[more]