Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Cue C
PROVIDER: S-EPMC7555886 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Martínez-Cué Carmen C Rueda Noemí N
International journal of molecular sciences 20200920 18
Down syndrome (DS), the most common cause of intellectual disability of genetic origin, is characterized by alterations in central nervous system morphology and function that appear from early prenatal stages. However, by the fourth decade of life, all individuals with DS develop neuropathology identical to that found in sporadic Alzheimer's disease (AD), including the development of amyloid plaques and neurofibrillary tangles due to hyperphosphorylation of tau protein, loss of neurons and synap ...[more]