Ontology highlight
ABSTRACT:
SUBMITTER: Sun C
PROVIDER: S-EPMC7556723 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Sun C C Dobi A A Mohamed A A Li H H Thangapazham R L RL Furusato B B Shaheduzzaman S S Tan S-H SH Vaidyanathan G G Whitman E E Hawksworth D J DJ Chen Y Y Nau M M Patel V V Vahey M M Gutkind J S JS Sreenath T T Petrovics G G Sesterhenn I A IA McLeod D G DG Srivastava S S
Oncogene 20080609 40
The high prevalence of TMPRSS2-ERG rearrangements ( approximately 60%) in prostate cancer (CaP) leads to androgenic induction of the ETS-related gene (ERG) expression. However, the biological functions of ERG overexpression in CaP remain to be understood. ERG knockdown in TMPRSS2-ERG expressing CaP cells induced striking morphological changes and inhibited cell growth both in cell culture and SCID mice. Evaluation of the transcriptome and specific gene promoters in ERG siRNA-treated cells and in ...[more]