Unknown

Dataset Information

0

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice.


ABSTRACT: Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.

SUBMITTER: Hadadi E 

PROVIDER: S-EPMC7314789 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7556830 | biostudies-literature
| S-EPMC7611611 | biostudies-literature
| S-EPMC2974025 | biostudies-literature
| S-EPMC7922568 | biostudies-literature
| S-EPMC6825145 | biostudies-literature
| S-EPMC7757029 | biostudies-literature
| S-EPMC6283862 | biostudies-other
| S-EPMC4371414 | biostudies-other
| S-SCDT-EMM-2021-14502 | biostudies-other
| S-EPMC8102873 | biostudies-literature