Ontology highlight
ABSTRACT:
SUBMITTER: Turner DL
PROVIDER: S-EPMC7556872 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Turner Declan L DL Korneev Denis V DV Purdy John G JG de Marco Alex A Mathias Rommel A RA
eLife 20200910
Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause of congenital birth defects, and poses serious risks for immuno-compromised individuals. To expand the molecular knowledge governing virion maturation, we analysed HCMV virions using proteomics, and identified a significant proportion of host exosome constituents. To validate this acquisition, we characterized exosomes released from uninfected cells, and demonstrated that over 99% of the protein cargo was s ...[more]