Ontology highlight
ABSTRACT:
SUBMITTER: Azad T
PROVIDER: S-EPMC7557813 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Azad Taha T Singaravelu Ragunath R Crupi Mathieu J F MJF Jamieson Taylor T Dave Jaahnavi J Brown Emily E F EEF Rezaei Reza R Taha Zaid Z Boulton Stephen S Martin Nikolas T NT Surendran Abera A Poutou Joanna J Ghahremani Mina M Nouri Kazem K Whelan Jack T JT Duong Jessie J Tucker Sarah S Diallo Jean-Simon JS Bell John C JC Ilkow Carolina S CS
Membranes 20200830 9
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic dr ...[more]