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A Self-Powered Biosensor for the Detection of Glutathione.

ABSTRACT: Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose oxidase anode and a bilirubin oxidase cathode. For the detection of glutathione, the inhibition of bilirubin oxidase leads to a measurable decrease in current and power output. The reported method has a detection limit of 0.043 mM and a linear range up to 1.7 mM. Being able to detect a range of concentrations can be useful in evaluating a patient's health. This method has the potential to be implemented as a quick, low-cost alternative to previously reported methods.

SUBMITTER: Roy BG

PROVIDER: S-EPMC7558183 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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A Self-Powered Biosensor for the Detection of Glutathione.

Roy Brandon G BG Rutherford Julia L JL Weaver Anna E AE Beaver Kevin K Rasmussen Michelle M

Biosensors 20200903 9

Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose oxidase anode and a bilirubin oxidase cathode. For the detection of glutathione, the inhibition of bilirubin oxidase leads to a measurable decrease in current and power output. The reported method has a detection limit of 0.043 mM and a linear range ...[more]

PMID: 32899114

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