Zinc(II)-The Overlooked Eminence Grise of Chloroquine's Fight against COVID-19?

ABSTRACT: Zn(II) is an inhibitor of SARS-CoV-2's RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.

SUBMITTER: Hecel A 

PROVIDER: S-EPMC7558363 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature