Zinc(II)-The Overlooked Eminence Grise of Chloroquine's Fight against COVID-19?
Ontology highlight
ABSTRACT:
SUBMITTER: Hecel A
PROVIDER: S-EPMC7558363 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?
Hecel Aleksandra A Ostrowska Małgorzata M Stokowa-Sołtys Kamila K Wątły Joanna J Dudek Dorota D Miller Adriana A Potocki Sławomir S Matera-Witkiewicz Agnieszka A Dominguez-Martin Alicia A Kozłowski Henryk H Rowińska-Żyrek Magdalena M
Pharmaceuticals (Basel, Switzerland) 20200901 9
Zn(II) is an inhibitor of <i>SARS-CoV-2</i>'s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention ...[more]
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