Ontology highlight
ABSTRACT:
SUBMITTER: Mola S
PROVIDER: S-EPMC7558485 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Mola Silvia S Pandolfo Chiara C Sica Antonio A Porta Chiara C
International journal of molecular sciences 20200918 18
Tumor-associated macrophages (TAMs) are the main population of myeloid cells infiltrating solid tumors and the pivotal orchestrators of cancer-promoting inflammation. However, due to their exceptional plasticity, macrophages can be also key effector cells and powerful activators of adaptive anti-tumor immunity. This functional heterogeneity is emerging in human tumors, colorectal cancer (CRC) in particular, where the dynamic co-existence of different macrophage subtypes influences tumor developm ...[more]