Ontology highlight
ABSTRACT:
SUBMITTER: Iudin D
PROVIDER: S-EPMC7558620 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Iudin Dmitrii D Zashikhina Natalia N Demyanova Elena E Korzhikov-Vlakh Viktor V Shcherbakova Elena E Boroznjak Roman R Tarasenko Irina I Zakharova Natalya N Lavrentieva Antonina A Skorik Yury Y Korzhikova-Vlakh Evgenia E
Pharmaceutics 20200911 9
Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin toxicity. Consequently, different delivery systems have been considered for polymyxins to overcome these obstacles. In this work, we report the development of polymyxin delivery systems based on nanoparticles obtained from the self-assembly of amphip ...[more]