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Frequency, prognosis and treatment modalities of newly diagnosed small bowel cancer with liver metastases.


ABSTRACT: BACKGROUND:Population-based analysis for the liver metastases of small bowel cancer is currently lacking. This study aimed to analyze the frequency, prognosis and treatment modalities for newly diagnosed small bowel cancer patients with liver metastases. METHODS:Patients with small bowel cancer diagnosed from 2010 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Binary logistic regression analysis was performed to determine predictors for the presence of liver metastases at diagnosis. Kaplan-Meier method and Cox regression analyses were performed for survival analyses. RESULTS:A total of 1461 small bowel cancer patients with liver metastases at initial diagnosis were identified, representing 16.5% of the entire set and 63.9% of the subset with metastatic disease to any distant site. Primary tumor with poorer histological type, larger tumor size, later N staging, more extrahepatic metastatic sites, and tumor on lower part of small intestine had increased propensity of developing liver metastases. The combined diagnostic model exhibited acceptable diagnostic efficiency with AUC value equal to 0.749. Patients with liver metastases had significant poorer survival (P?

SUBMITTER: Ye X 

PROVIDER: S-EPMC7558693 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Frequency, prognosis and treatment modalities of newly diagnosed small bowel cancer with liver metastases.

Ye Xiaorong X   Wang Lifu L   Xing Yongjun Y   Song Chengjun C  

BMC gastroenterology 20201015 1


<h4>Background</h4>Population-based analysis for the liver metastases of small bowel cancer is currently lacking. This study aimed to analyze the frequency, prognosis and treatment modalities for newly diagnosed small bowel cancer patients with liver metastases.<h4>Methods</h4>Patients with small bowel cancer diagnosed from 2010 to 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Binary logistic regression analysis was performed to determine predictors fo  ...[more]

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