Dataset Information

A transgender man, a cisgender woman, and assisted reproductive technologies: a Brazilian case report.

ABSTRACT: Transgender men are individuals who identify as men but were assigned female at birth. Gender-af?rming medications include testosterone hormone therapy, known for its diverse e?ects throughout the body, which include endometrial atrophy and the induction of amenorrhea by suppressing ovulation, without however affecting the ovarian follicle pool. This paper reports the first case in Brazil involving a transgender man and a cisgender woman attempting to form a family. A 34-year-old transgender man and a 28-year-old woman came to our assisted reproduction service. He had been on testosterone for two years. At their initial consultation, testosterone therapy was discontinued. Controlled ovarian stimulation for the transgender man was achieved using a combination of recombinant gonadotropins FSH and LH. Pituitary blockage was performed using a GnRH antagonist protocol. Twenty follicles were aspirated and 16 oocytes were retrieved, 12 of which mature. They were inseminated with donor semen. On the fifth day of development, one high quality blastocyst was transferred to the cisgender woman, resulting in an ongoing pregnancy. Five supernumerary embryos were cryopreserved. Controlled ovarian stimulation with high quality oocytes, high quality embryos, and clinical pregnancy are possible for transgender men, even with a history of testosterone use.

SUBMITTER: Resende SS

PROVIDER: S-EPMC7558884 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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A transgender man, a cisgender woman, and assisted reproductive technologies: a Brazilian case report.

Resende Suely de Sousa SS Kussumoto Vitor Hugo VH Arima Flávia Harumi Cardoso FHC Krul Priscila Cristine PC Rodovalho Norma Cléa Mesquita NCM Sampaio Maria Risalva de Jesus MRJ Alves Mayara Muneishi MM

JBRA assisted reproduction 20201006 4

Transgender men are individuals who identify as men but were assigned female at birth. Gender-afﬁrming medications include testosterone hormone therapy, known for its diverse eﬀects throughout the body, which include endometrial atrophy and the induction of amenorrhea by suppressing ovulation, without however affecting the ovarian follicle pool. This paper reports the first case in Brazil involving a transgender man and a cisgender woman attempting to form a family. A 34-year-old transgender man ...[more]

PMID: 32469193

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Project description:Societal changes and the increasing desire and opportunity to preserve fertility have increased the demand for effective assisted reproductive technologies (ART) and have increased the range of scenarios in which ART is now used. In recent years, the "freeze-all" strategy of cryopreserving all oocytes or good quality embryos produced in an IVF cycle to transfer later-at a time that is more appropriate for reasons of medical need, efficacy, or desirability-has emerged as an accepted and valuable alternative to fresh embryo transfer. Indeed, improvements in cryopreservation techniques (vitrification) and the development of more efficient ovarian stimulation protocols have facilitated a dramatic increase in the practice of elective frozen embryo transfer (eFET). Alongside these advances, debate continues about whether eFET should be a standard treatment option available to the whole IVF population or if it is important to identify patient subgroups who are most likely to benefit from such an approach. Achieving successful outcomes in ART, whether by fresh or frozen embryo transfer, is influenced by a wide range of factors. As well as the efficiency of IVF and embryo transfer protocols and techniques, factors affecting implantation include maternal aging, sperm quality, the vaginal and endometrial microbiome, and peri-implantation levels of serum progesterone. The safety of eFET, both during ART cycles and on longer-term obstetric and neonatal outcomes, is also an important consideration. In this review, we explore the benefits and risks of freeze-all strategies in different scenarios. We review available evidence on the outcomes achieved with elective cryopreservation strategies and practices and how these compare with more traditional IVF cycles with fresh embryo transfers, both in the general IVF population and in subgroups of special interest. In addition, we consider how to optimize and individualize "freeze-all" procedures to achieve successful reproductive outcomes.

Dataset Information

A transgender man, a cisgender woman, and assisted reproductive technologies: a Brazilian case report.

Publications

A transgender man, a cisgender woman, and assisted reproductive technologies: a Brazilian case report.

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