Ontology highlight
ABSTRACT:
SUBMITTER: Yu WH
PROVIDER: S-EPMC7559243 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yu Wei-Hsuan WH Wu Erxi E Li Yongqing Y Hou Hsin-Han HH Yu Shuan-Su C SC Huang Po-Tsang PT Kuo Wen-Hung WH Qi Dan D Yu Chong-Jen CJ
iScience 20200923 10
The enlarged distinct bulky-ball-like nucleolus matrix assembly is observed in most cancer stem cells (CSCs); however, the underlying mechanism is largely unknown. We show that matrix metalloproteinase-7 (MMP-7) shedding MUC-1 SEA domain releases MUC-1 C-ter, facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung CSCs. The nucleolus colocalizations of p53, MUC-1 C-ter, MMP-7 and nucleolin were observed in the CD34<sup>+</sup> CXADR<sup>+</sup> CD44v<sub>3</sub> <sup>+</sup> ge ...[more]