Ontology highlight
ABSTRACT:
SUBMITTER: Perreault AA
PROVIDER: S-EPMC7559257 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Perreault Andrea A AA Brown Jonathan D JD Venters Bryan J BJ
iScience 20200920 10
The three-dimensional architecture of the genome plays an essential role in establishing and maintaining cell identity. However, the magnitude and temporal kinetics of changes in chromatin structure that arise during cell differentiation remain poorly understood. Here, we leverage a murine model of erythropoiesis to study the relationship between chromatin conformation, the epigenome, and transcription in erythroid cells. We discover that acute transcriptional responses induced by erythropoietin ...[more]