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Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways.

ABSTRACT: Global environmental pollution has led to human exposure to ultraviolet (UV) radiation due to the damaged ozone layer, thereby increasing the incidence and death rate of skin cancer including both melanoma and non-melanoma. Overexpression and activation of V-akt murine thymoma viral oncogene homolog (AKT, also known as protein kinase B) and related signaling pathways are major factors contributing to many cancers including lung cancer, esophageal squamous cell carcinoma and skin cancer. Although BRAF inhibitors are used to treat melanoma, further options are needed due to treatment resistance and poor efficacy. Depletion of AKT expression and activation, and related signaling cascades by its inhibitors, decreases the growth of skin cancer and metastasis. Here we have focused the effects of AKT and related signaling (PI3K/AKT/mTOR) pathways by regulators derived from plants and suggest the need for efficient treatment in skin cancer therapy.

SUBMITTER: Hwang SY 

PROVIDER: S-EPMC7560163 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways.

Hwang Sun-Young SY   Chae Jung-Il JI   Kwak Ah-Won AW   Lee Mee-Hyun MH   Shim Jung-Hyun JH  

International journal of molecular sciences 20200918 18

Global environmental pollution has led to human exposure to ultraviolet (UV) radiation due to the damaged ozone layer, thereby increasing the incidence and death rate of skin cancer including both melanoma and non-melanoma. Overexpression and activation of V-akt murine thymoma viral oncogene homolog (AKT, also known as protein kinase B) and related signaling pathways are major factors contributing to many cancers including lung cancer, esophageal squamous cell carcinoma and skin cancer. Although  ...[more]

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