Ontology highlight
ABSTRACT:
SUBMITTER: Ramani A
PROVIDER: S-EPMC7560208 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ramani Anand A Müller Lisa L Ostermann Philipp N PN Gabriel Elke E Abida-Islam Pranty P Müller-Schiffmann Andreas A Mariappan Aruljothi A Goureau Olivier O Gruell Henning H Walker Andreas A Andrée Marcel M Hauka Sandra S Houwaart Torsten T Dilthey Alexander A Wohlgemuth Kai K Omran Heymut H Klein Florian F Wieczorek Dagmar D Adams Ortwin O Timm Jörg J Korth Carsten C Schaal Heiner H Gopalakrishnan Jay J Gopalakrishnan Jay J
The EMBO journal 20200923 20
COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imagin ...[more]