Unknown

Dataset Information

0

SARS-CoV-2 targets neurons of 3D human brain organoids.


ABSTRACT: COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19.

SUBMITTER: Ramani A 

PROVIDER: S-EPMC7560208 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imagin  ...[more]

Similar Datasets

| S-EPMC8111796 | biostudies-literature
| S-EPMC7551632 | biostudies-literature
| S-EPMC7399356 | biostudies-literature
| S-EPMC9533278 | biostudies-literature
| S-EPMC7553118 | biostudies-literature
| S-EPMC7911731 | biostudies-literature
| S-EPMC8595698 | biostudies-literature
| S-EPMC9765283 | biostudies-literature
| S-EPMC7479826 | biostudies-literature
| S-EPMC8550698 | biostudies-literature