Ontology highlight
ABSTRACT:
SUBMITTER: Yepes S
PROVIDER: S-EPMC7560829 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yepes Sally S Tucker Margaret A MA Koka Hela H Xiao Yanzi Y Jones Kristine K Vogt Aurelie A Burdette Laurie L Luo Wen W Zhu Bin B Hutchinson Amy A Yeager Meredith M Hicks Belynda B Freedman Neal D ND Chanock Stephen J SJ Goldstein Alisa M AM Yang Xiaohong R XR
Scientific reports 20201014 1
Although next-generation sequencing has demonstrated great potential for novel gene discovery, confirming disease-causing genes after initial discovery remains challenging. Here, we applied a network analysis approach to prioritize candidate genes identified from whole-exome sequencing analysis of 98 cutaneous melanoma patients from 27 families. Using a network propagation method, we ranked candidate genes by their similarity to known disease genes in protein-protein interaction networks and ide ...[more]