Ontology highlight
ABSTRACT:
SUBMITTER: O'Regan GC
PROVIDER: S-EPMC7560844 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
O'Regan Grace C GC Farag Sahar H SH Ostroff Gary R GR Tabrizi Sarah J SJ Andre Ralph R
Scientific reports 20201014 1
The huntingtin (HTT) protein in its mutant form is the cause of the inherited neurodegenerative disorder, Huntington's disease. Beyond its effects in the central nervous system, disease-associated mutant HTT causes aberrant phenotypes in myeloid-lineage innate immune system cells, namely monocytes and macrophages. Whether the wild-type form of the protein, however, has a role in normal human macrophage function has not been determined. Here, the effects of lowering the expression of wild-type (w ...[more]