Ontology highlight
ABSTRACT:
SUBMITTER: Pistorius K
PROVIDER: S-EPMC6024030 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Pistorius Kimberly K Souza Patricia R PR De Matteis Roberta R Austin-Williams Shani S Primdahl Karoline G KG Vik Anders A Mazzacuva Francesca F Colas Romain A RA Marques Raquel M RM Hansen Trond V TV Dalli Jesmond J
Cell chemical biology 20180524 6
Macrophages are central in orchestrating the clearance of apoptotic cells and cellular debris during inflammation, with the mechanism(s) regulating this process remaining of interest. Herein, we found that the n-3 docosapentaenoic acid-derived protectin (PD<sub>n-3 DPA</sub>) biosynthetic pathway regulated the differentiation of human monocytes, altering macrophage phenotype, efferocytosis, and bacterial phagocytosis. Using lipid mediator profiling, human primary cells and recombinant enzymes we ...[more]