Learning Cell-Type-Specific Gene Regulation Mechanisms by Multi-Attention Based Deep Learning With Regulatory Latent Space.
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ABSTRACT:
SUBMITTER: Kang M
PROVIDER: S-EPMC7561362 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Learning Cell-Type-Specific Gene Regulation Mechanisms by Multi-Attention Based Deep Learning With Regulatory Latent Space.
Kang Minji M Lee Sangseon S Lee Dohoon D Kim Sun S
Frontiers in genetics 20200930
Epigenetic gene regulation is a major control mechanism of gene expression. Most existing methods for modeling control mechanisms of gene expression use only a single epigenetic marker and very few methods are successful in modeling complex mechanisms of gene regulations using multiple epigenetic markers on transcriptional regulation. In this paper, we propose a multi-attention based deep learning model that integrates multiple markers to characterize complex gene regulation mechanisms. In exper ...[more]
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