Ontology highlight
ABSTRACT:
SUBMITTER: Julien A
PROVIDER: S-EPMC7561512 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Julien Anais A Perrin Simon S Duchamp de Lageneste Oriane O Carvalho Caroline C Bensidhoum Morad M Legeai-Mallet Laurence L Colnot Céline C
Stem cell reports 20200910 4
Most organs and tissues in the body, including bone, can repair after an injury due to the activation of endogenous adult stem/progenitor cells to replace the damaged tissue. Inherent dysfunctions of the endogenous stem/progenitor cells in skeletal repair disorders are still poorly understood. Here, we report that Fgfr3<sup>Y637C/+</sup> over-activating mutation in Prx1-derived skeletal stem/progenitor cells leads to failure of fracture consolidation. We show that periosteal cells (PCs) carrying ...[more]