Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats.
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ABSTRACT:
SUBMITTER: Ebokaiwe AP
PROVIDER: S-EPMC7561705 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats.
Ebokaiwe Azubuike P AP Okori Stephen S Nwankwo Joseph O JO Ejike Chukwunonso E C C CECC Osawe Sharon O SO
Naunyn-Schmiedeberg's archives of pharmacology 20201016 4
Selenium nanoparticles (SeNPs) are well reported to exhibit pharmacological activities both in vitro and in vivo. However, literature is devoid of studies on the impact of SeNPs and/or metformin (M) against streptozotocin (STZ)-mediated oxidative brain injury and behavioral impairment. Consequently, to fill this gap, diabetes was induced in male Wistar rats by feeding with 10% fructose solution for 2 weeks, followed by a single dose intraperitoneal injection of STZ (40 mg/kg body weight [bwt]). ...[more]
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