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Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.

ABSTRACT: The major obstacles of optical imaging and photothermal therapy in biomedical applications is the strong scattering of light within biological tissues resulting in light defocusing and limited penetration. In this study, we propose high intensity focused ultrasound (HIFU)-induced heating tunnel to reduce the photon scattering. To verify our idea, Monte Carlo simulation and intralipid-phantom experiments were conducted. The results show that the thermal effect created by HIFU could improve the light fluence at the targeted region by 3% in both simulation and phantom experiments. Owing to the fluence increase, similar results can also be found in the photoacoustic experiments. In conclusion, our proposed method shows a noninvasive way to increase the light delivery efficiency in turbid medium. It is expected that our finding has a potential for improving the focal light delivery in photoacoustic imaging and photothermal therapy.

SUBMITTER: Hsieh ZH

PROVIDER: S-EPMC7562700 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.

Hsieh Zong-Han ZH Fan Ching-Hsiang CH Ho Yi-Ju YJ Li Meng-Lin ML Yeh Chih-Kuang CK

Scientific reports 20201015 1

The major obstacles of optical imaging and photothermal therapy in biomedical applications is the strong scattering of light within biological tissues resulting in light defocusing and limited penetration. In this study, we propose high intensity focused ultrasound (HIFU)-induced heating tunnel to reduce the photon scattering. To verify our idea, Monte Carlo simulation and intralipid-phantom experiments were conducted. The results show that the thermal effect created by HIFU could improve the li ...[more]

PMID: 33060643

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Project description:Nanoparticles find widespread application in various medical contexts, including targeted nanomedicine and enhancing therapeutic efficacy. Moreover, they are employed to stabilize emulsions, giving rise to stabilized droplets known as Pickering droplets. Among the various methods to improve anti-cancer treatment, ultrasound hyperthermia stands out as an efficient approach. This research proposes Pickering droplets as promising sonosensitizer candidates, to enhance the attenuation of ultrasound with simultaneous potential to act as drug carriers. The enhanced ultrasound energy dissipation could be, therefore, optimized by changing the parameters of Pickering droplets. The ultrasound scattering theory, based on the core-shell model, was employed to calculate theoretical ultrasound properties such as attenuation and velocity. Additionally, computer simulations, based on a bioheat transfer model, were utilized to compute heat generation in agar-based phantoms of tissues under different ultrasound wave frequencies. Two types of phantoms were simulated: a pure agar phantom and an agar phantom incorporating spherical inclusions. The spherical inclusions, with a diameter of 10 mm, were doped with various sizes of Pickering droplets, considering their core radius and shell thickness. Computer simulation of these spherical inclusions incorporated within agar phantom resulted in different enhancement of achieved temperature elevation, which depending on the core radius, shell thickness, and the material properties of the system. Notably, spherical inclusions doped with Pickering droplets stabilized by magnetite nanoparticles exhibited a higher temperature rise compared to droplets stabilized by silica nanoparticles. Moreover, nanodroplets with a core radius below 400 nm demonstrated better heating performance compared to microdroplets. Furthermore, Pickering droplets incorporated into agar phantom could allow obtaining a similar effect of local heating as sophisticated focused ultrasound devices.

Project description:BackgroundOncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors.MethodsAdenovirus (Ad) was "stealthed" with a new N-(2-hydroxypropyl)methacrylamide polymer, and circulation kinetics were characterized in Balb/C SCID mice (n = 8 per group) bearing human ZR-75-1 xenograft tumors. Then, to noninvasively increase extravasation of the circulating polymer-coated Ad into the tumor, it was coinjected with gas microbubbles and the tumor was exposed to 0.5 MHz focused ultrasound at peak rarefactional pressure of 1.2 MPa. These ultrasound exposure conditions were designed to trigger inertial cavitation, an acoustic phenomenon that produces shock waves and can be remotely monitored in real-time. Groups were compared with Student t test or one-way analysis of variance with Tukey correction where groups were greater than two. All statistical tests were two-sided.ResultsPolymer-coating of Ad reduced hepatic sequestration, infection (>8000-fold; P < .001), and toxicity and improved circulation half-life (>50-fold; P = .001). Combination of polymer-coated Ad, gas bubbles, and focused ultrasound enhanced tumor infection >30-fold; (4 × 10(6) photons/sec/cm(2); standard deviation = 3 × 10(6) with ultrasound vs 1.3 × 10(5); standard deviation = 1 × 10(5) without ultrasound; P = .03) and penetration, enabling kill of cells more than 100 microns from the nearest blood vessel. This led to substantial and statistically significant retardation of tumor growth and increased survival.ConclusionsCombining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer.

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Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.

Publications

Improvement of light penetration in biological tissue using an ultrasound-induced heating tunnel.

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