Ontology highlight
ABSTRACT:
SUBMITTER: Tojo S
PROVIDER: S-EPMC7562955 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Tojo Shingo S Zhang Zhikuan Z Matsui Hiroyuki H Tahara Masahiro M Ikeguchi Mitsunori M Kochi Mami M Kamada Mami M Shigematsu Hideki H Tsutsumi Akihisa A Adachi Naruhiko N Shibata Takuma T Yamamoto Masaki M Kikkawa Masahide M Senda Toshiya T Isobe Yoshiaki Y Ohto Umeharu U Shimizu Toshiyuki T
Nature communications 20201015 1
Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune diseases including systemic lupus erythematosus (SLE). Here, by modifying potent TLR7 agonists, we develop a series of TLR7-specific antagonists as promising therapeutic agents for SLE. These compounds protect mice against lethal autoimmunity. Combining crystallography and cryo-electron microscopy, we identify the open conformation of th ...[more]