Ontology highlight
ABSTRACT:
SUBMITTER: Reinert LS
PROVIDER: S-EPMC5109551 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Reinert Line S LS Lopušná Katarína K Winther Henriette H Sun Chenglong C Thomsen Martin K MK Nandakumar Ramya R Mogensen Trine H TH Meyer Morten M Vægter Christian C Nyengaard Jens R JR Fitzgerald Katherine A KA Paludan Søren R SR
Nature communications 20161110
Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression in CNS cells and these cytokines are induced in a cGAS-STING-dependent manner. Consistently, mice defective in cGAS or STING are highly susceptible to acute HSE. Although STING is re ...[more]