Ontology highlight
ABSTRACT:
SUBMITTER: Nath Neerukonda S
PROVIDER: S-EPMC7563823 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nath Neerukonda Sabari S Vassell Russell R Weiss Carol D CD
Vaccines 20200712 3
Influenza continues to be a public health threat despite the availability of annual vaccines. While vaccines are generally effective at inducing strain-specific immunity, they are sub-optimal or ineffective when drifted or novel pandemic strains arise due to sequence changes in the major surface glycoprotein hemagglutinin (HA). The discovery of a large number of antibodies targeting the highly conserved stem region of HAs that are capable of potently neutralizing a broad range of virus strains a ...[more]