Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management.
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ABSTRACT:
SUBMITTER: Dork T
PROVIDER: S-EPMC7565375 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management.
Dörk Thilo T Hillemanns Peter P Tempfer Clemens C Breu Julius J Fleisch Markus C MC
Cancers 20200825 9
Endometrial cancer (EC) is the most common cancer affecting the female reproductive organs in higher-income states. Apart from reproductive factors and excess weight, genetic predisposition is increasingly recognized as a major factor in endometrial cancer risk. Endometrial cancer is genetically heterogeneous: while a subgroup of patients belongs to cancer predisposition syndromes (most notably the Lynch Syndrome) with high to intermediate lifetime risks, there are also several common genomic po ...[more]
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