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New Insights into the Role of Sphingolipid Metabolism in Melanoma.

ABSTRACT: Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated in melanoma and is associated with melanoma progression and resistance to treatment. This review summarises the impact of the sphingolipid metabolism on melanoma from the initiation to metastatic dissemination with emphasis on melanoma plasticity, immune responses and resistance to treatments.

SUBMITTER: Carrie L

PROVIDER: S-EPMC7565650 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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New Insights into the Role of Sphingolipid Metabolism in Melanoma.

Carrié Lorry L Virazels Mathieu M Dufau Carine C Montfort Anne A Levade Thierry T Ségui Bruno B Andrieu-Abadie Nathalie N

Cells 20200826 9

Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated ...[more]

PMID: 32858889

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