Ontology highlight
ABSTRACT:
SUBMITTER: Carrie L
PROVIDER: S-EPMC7565650 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Carrié Lorry L Virazels Mathieu M Dufau Carine C Montfort Anne A Levade Thierry T Ségui Bruno B Andrieu-Abadie Nathalie N
Cells 20200826 9
Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated ...[more]