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Utilitarian redundancy in local medical systems - theoretical and methodological contributions.

ABSTRACT: The utilitarian redundancy model (URM) is one of the recent contributions to ethnobiology. We argue that URM can be applied to access use-pressure on plant species, the resilience of socioecological systems (e.g., local medical systems), cultural keystone species, and the role of exotic species in social-ecological systems. Based on previous URM studies, we also emphasize the need to differ practical (considering plants and uses that are currently employed) and theoretical (considering both currently employed and potentially employed plants and uses) redundancy. Based on the main applications of the URM, we propose a new index to access redundancy of a therapeutic indication: the Uredit, so that Uredit = NSp + CR, were Uredit is the Utilitarian Redundancy Index for the therapeutic indication; NSp is the total number of species mentioned for the indication, and CR is the species' contribution to redundancy (in terms of knowledge sharing). The maximum value that the Uredit could reach is twice the number of species employed for the therapeutic indication. We believe that this theoretical and methodological improvement in the model can improve comparisons of redundancy in different social-ecological systems. We also highlight some limitations of the URM (and our Uredit), and we believe that conscious reasons behind people's decisions should be incorporated into future studies on the subject.

SUBMITTER: de Medeiros PM

PROVIDER: S-EPMC7565813 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Utilitarian redundancy in local medical systems - theoretical and methodological contributions.

de Medeiros Patrícia Muniz PM Ferreira Júnior Washington Soares WS Queiroz Fabiane da Silva FDS

Journal of ethnobiology and ethnomedicine 20201016 1

The utilitarian redundancy model (URM) is one of the recent contributions to ethnobiology. We argue that URM can be applied to access use-pressure on plant species, the resilience of socioecological systems (e.g., local medical systems), cultural keystone species, and the role of exotic species in social-ecological systems. Based on previous URM studies, we also emphasize the need to differ practical (considering plants and uses that are currently employed) and theoretical (considering both curr ...[more]

PMID: 33066790

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Project description:Resilience is related to the ability of a system to adjust to disturbances. The Utilitarian Redundancy Model has emerged as a tool for investigating the resilience of local medical systems. The model determines the use of species richness for the same therapeutic function as a facilitator of the maintenance of these systems. However, predictions generated from this model have not yet been tested, and a lack of variables exists for deeper analyses of resilience. This study aims to address gaps in the Utilitarian Redundancy Model and to investigate the resilience of two medical systems in the Brazilian semi-arid zone. As a local illness is not always perceived in the same way that biomedicine recognizes, the term "therapeutic targets" is used for perceived illnesses. Semi-structured interviews with local experts were conducted using the free-listing technique to collect data on known medicinal plants, usage preferences, use of redundant species, characteristics of therapeutic targets, and the perceived severity for each target. Additionally, participatory workshops were conducted to determine the frequency of targets. The medical systems showed high species richness but low levels of species redundancy. However, if redundancy was present, it was the primary factor responsible for the maintenance of system functions. Species richness was positively associated with therapeutic target frequencies and negatively related to target severity. Moreover, information about redundant species seems to be largely idiosyncratic; this finding raises questions about the importance of redundancy for resilience. We stress the Utilitarian Redundancy Model as an interesting tool to be used in studies of resilience, but we emphasize that it must consider the distribution of redundancy in terms of the treatment of important illnesses and the sharing of information. This study has identified aspects of the higher and lower vulnerabilities of medical systems, adding variables that should be considered along with richness and redundancy.

Project description:UnlabelledBackgroundRecently, various metallocenes were synthesized and analyzed by biological activity point of view (such as antiproliferative properties): ruthenocenes, cobaltoceniums, titanocenes, zirconocenes, vanadocenes, niobocenes, molibdocenes etc. Two main disadvantages of metallocenes are the poor hydrosolubility and the hydrolytic instability. These problems could be resolved in two ways: synthetically modifying the structure or finding new formulations with enhanced properties. The aqueous solubility of metallocenes with cytostatic activities could be enhanced by molecular encapsulation in cyclodextrins, as well as the hydrolytic instability of these compounds could be reduced.ResultsThis study presents a theoretical approach on the nanoencapsulation of a series of titanocenes with cytotoxic activity in ?-, ?-, and ?-cyclodextrin. The HyperChem 5.11 package was used for building and molecular modelling of titanocene and cyclodextrin structures, as well as for titanocene/cyclodextrin complex optimization. For titanocene/cyclodextrin complex optimization experiments, the titanocene and cyclodextrin structures in minimal energy conformations were set up at various distances and positions between molecules (molecular mechanics functionality, MM+). The best interaction between titanocene structures and cyclodextrins was obtained in the case of ?- and ?-cyclodextrin, having the hydrophobic moieties oriented to the secondary face of cyclodextrin. The hydrophobicity of titanocenes (logP) correlate with the titanocene-cyclodextrin interaction parameters, especially with the titanocene-cyclodextrin interaction energy; the compatible geometry and the interaction energy denote that the titanocene/?- and ?-cyclodextrin complex can be achieved. Valuable quantitative structure-activity relationships (QSARs) were also obtained in the titanocene class by using the same logP as the main parameter for the in vitro cytotoxic activity against HeLa, K562, and Fem-x cell lines.ConclusionsAccording to our theoretical study, the titanocene/cyclodextrin inclusion compounds can be obtained (high interaction energy; the encapsulation is energetically favourable). Further, the most hydrophobic compounds are better encapsulated in ?- and ?-cyclodextrin molecules and are more stable (from energetically point of view) in comparison with ?-cyclodextrin case. This study suggests that the titanocene / ?- and ?-cyclodextrin complexes (or synthetically modified cyclodextrins with higher water solubility) could be experimentally synthesized and could have enhanced cytotoxic activity and even lower toxicity.

Project description:Clinical evidence available for the assessment of medical devices (MDs) is frequently insufficient. New MDs should be subjected to high quality clinical studies to demonstrate their benefit to patients. The randomized controlled trial (RCT) is the study design reaching the highest level of evidence in order to demonstrate the efficacy of a new MD. However, the clinical context of some MDs makes it difficult to carry out a conventional RCT. The objectives of this review are to present problems related to conducting conventional RCTs and to identify other experimental designs, their limitations, and their applications. A systematic literature search was conducted for the period January 2000 to July 2012 by searching medical bibliographic databases. Problems related to conducting conventional RCTs of MDs were identified: timing the assessment, eligible population and recruitment, acceptability, blinding, choice of comparator group, and learning curve. Other types of experimental designs have been described. Zelen's design trials and randomized consent design trials facilitate the recruitment of patients, but can cause ethical problems to arise. Expertise-based RCTs involve randomization to a team that specializes in a given intervention. Sometimes, the feasibility of an expertise-based randomized trial may be greater than that of a conventional trial. Cross-over trials reduce the number of patients, but are not applicable when a learning curve is required. Sequential trials have the advantage of allowing a trial to be stopped early depending on the results of first inclusions, but they require an independent committee. Bayesian methods combine existing information with information from the ongoing trial. These methods are particularly useful in situations where the number of subjects is small. The disadvantage is the risk of including erroneous prior information. Other types of experimental designs exist when conventional trials cannot always be applied to the clinical development of MDs.

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Utilitarian redundancy in local medical systems - theoretical and methodological contributions.

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Utilitarian redundancy in local medical systems - theoretical and methodological contributions.

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