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The Landscape of Tumor-Specific Antigens in Colorectal Cancer.


ABSTRACT: Over the last few decades, major efforts in cancer research and treatment have intensified. Apart from standard chemotherapy approaches, immunotherapy has gained substantial traction. Personalized immunotherapy has become an important tool for cancer therapy with the discovery of immune checkpoint inhibitors. Traditionally, tumor-associated antigens are used in immunotherapy-based treatments. Nevertheless, these antigens lack specificity and may have increased toxicity. With the advent of next-generation technologies, the identification of new tumor-specific antigens is becoming more important. In colorectal cancer, several tumor-specific antigens were identified and functionally validated. Multiple clinical trials from vaccine-based and adoptive cell therapy utilizing tumor-specific antigens have commenced. Herein, we will summarize the current landscape of tumor-specific antigens particularly in colorectal cancer.

SUBMITTER: Rus Bakarurraini NAA 

PROVIDER: S-EPMC7565947 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The Landscape of Tumor-Specific Antigens in Colorectal Cancer.

Rus Bakarurraini Nurul Ainaa Adilah NAA   Ab Mutalib Nurul Syakima NS   Jamal Rahman R   Abu Nadiah N  

Vaccines 20200710 3


Over the last few decades, major efforts in cancer research and treatment have intensified. Apart from standard chemotherapy approaches, immunotherapy has gained substantial traction. Personalized immunotherapy has become an important tool for cancer therapy with the discovery of immune checkpoint inhibitors. Traditionally, tumor-associated antigens are used in immunotherapy-based treatments. Nevertheless, these antigens lack specificity and may have increased toxicity. With the advent of next-g  ...[more]

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