Ontology highlight
ABSTRACT:
SUBMITTER: Stevanovic S
PROVIDER: S-EPMC6295311 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Stevanović Sanja S Pasetto Anna A Helman Sarah R SR Gartner Jared J JJ Prickett Todd D TD Howie Bryan B Robins Harlan S HS Robbins Paul F PF Klebanoff Christopher A CA Rosenberg Steven A SA Hinrichs Christian S CS
Science (New York, N.Y.) 20170401 6334
Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor antigens targeted in successful treatments remain poorly defined. We used a personalized immunogenomic approach to elucidate the global landscape of antitumor T cell responses in complete regression of human papillomavirus-associated metastatic cervical cancer after tumor-infiltrating adoptive T cell therapy. Remarkably, immunodominant T cell reactivities were directed against mutated neoantigens or a c ...[more]