Maltotriose Conjugated Metal-Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages.
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ABSTRACT:
SUBMITTER: Sakamaki Y
PROVIDER: S-EPMC7567337 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Maltotriose Conjugated Metal-Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages.
Sakamaki Yoshie Y Ozdemir John J Perez Alda Diaz AD Heidrick Zachary Z Watson Olivia O Tsuji Miu M Salmon Chirstopher C Batta-Mpouma Joseph J Azzun Anthony A Lomonte Valerie V Du Yuchun Y Stenken Julie J Woo-Kim Jin J Beyzavi M Hassan MH
Advanced therapeutics 20200608 8
Herein, we report a nano-MOF conjugated to maltotriose as a new DDS. MA-PCN-224-0.1Mn/0.9Zn showed its ability to target cancer and TAM. This novel MOF is an effective PDT agent and shows little dark toxicity, MA-PCN-224-0.1Mn/0.9Zn uptakes selectively into cancer cells. A well-suited size control methodology was used so that the nano-scaled MOFs may take advantage of the EPR effect. This development of a nano-scale MOF for PDT that is conjugated to a cancer targeting ligand represents a meaning ...[more]
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