Ontology highlight
ABSTRACT:
SUBMITTER: Saito E
PROVIDER: S-EPMC7567592 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Saito Eiji E Gurczynski Stephen J SJ Kramer Kevin R KR Wilke Carol A CA Miller Stephen D SD Moore Bethany B BB Shea Lonnie D LD
Science advances 20201016 42
Antigen-specific particles can treat autoimmunity, and pulmonary delivery may provide for easier delivery than intravenous or subcutaneous routes. The lung is a "hub" for autoimmunity where autoreactive T cells pass before arriving at disease sites. Here, we report that targeting lung antigen-presenting cells (APCs) via antigen-loaded poly(lactide-<i>co</i>-glycolide) particles modulates lung CD4<sup>+</sup> T cells to tolerize murine experimental autoimmune encephalomyelitis (EAE), a mouse mode ...[more]