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In vivo measurement of shear modulus of the human cornea using optical coherence elastography.

ABSTRACT: Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86?±?0.75 m/s, corresponding to a shear modulus of 72?±?14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13-18 mmHg, and shear modulus decreases with age (-?0.32?±?0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring.

SUBMITTER: Ramier A

PROVIDER: S-EPMC7567833 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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In vivo measurement of shear modulus of the human cornea using optical coherence elastography.

Ramier Antoine A Eltony Amira M AM Chen YiTong Y Clouser Fatima F Birkenfeld Judith S JS Watts Amy A Yun Seok-Hyun SH

Scientific reports 20201015 1

Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear mo ...[more]

PMID: 33060714

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Dataset Information

In vivo measurement of shear modulus of the human cornea using optical coherence elastography.

Publications

In vivo measurement of shear modulus of the human cornea using optical coherence elastography.

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