Ontology highlight
ABSTRACT:
SUBMITTER: Bohme J
PROVIDER: S-EPMC7567856 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nature communications 20201016 1
Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic understanding of these protective effects is lacking. Here, we use mass cytometry to show that metformin treatment expands a population of memory-like antigen-inexperienced CD8<sup>+</sup>CXCR3<sup>+</sup> T cells in naive mice, and in healthy indivi ...[more]